Background: Antimicrobial resistance among Enterobacterales continues to be a growing problem, particularly in those with urinary infections. Previous studies have demonstrated safety and efficacy with the use of single-dose aminoglycosides in uncomplicated cystitis. However, data in complicated infections are limited. Single-dose aminoglycosides may provide a convenient alternative for those with or at risk for resistant pathogens causing complicated urinary infections, especially when oral options are unavailable due to resistance, allergy, intolerance, or interactions with other medications.
This study evaluated the safety and effectiveness of single-dose aminoglycosides in treatment of complicated cystitis in the emergency department ED. Methods: This was a multicenter, prospective study performed between July and March of patients who met criteria for complicated cystitis and were otherwise stable for discharge at an academic ED.
Primary outcomes were clinical or microbiologic failure within 14 days of treatment. Safety was assessed by review of adverse events. Descriptive statistics were used.
Results: Thirteen patients were included. No patient required hospital admission for treatment failure, and no adverse events were noted. Conclusions: Single-dose aminoglycosides appear to be a reasonably effective and safe treatment for complicated cystitis, which avoided hospital admission in this cohort. Abstract Background: Antimicrobial resistance among Enterobacterales continues to be a growing problem, particularly in those with urinary infections.
Publication types Multicenter Study. Substances Aminoglycosides Anti-Bacterial Agents.
