Official websites use. Share sensitive information only on official, secure websites. Correspondence to Sabine Oertelt-Prigione; sabine. Clinical practice guidelines CPGs are a powerful instrument to ensure evidence-based practice in clinical diagnostics and disease management.
As knowledge about the impact of sex and gender on health and disease is emerging, the need for its transfer into clinical practice is becoming more urgent. However, a systematic evaluation of the incorporation of sex-related and gender-related knowledge into CPGs in Europe is currently not available.
This systematic review will fill this gap. We will analyse the operationalisation of sex and gender in internal medicine CPGs in Europe and the translation of this information into tailored recommendations. The results will offer a baseline assessment to inform prospective sex-sensitive and gender-sensitive guideline development.
CPGs published by European internal medicine guidelines will be analysed according to a pre-established analysis framework. CPGs will be identified by a two-step approach, that is, through direct contact with the organisations and by a PubMed search, to ensure capture of all relevant guidelines. Prespecified keywords will be employed to identify the representation of sex-related and gender-related content throughout the CPGs.
Structured data will be collected through machine-assisted text mining. Identified texts will then be manually reviewed by two independent coders using a specifically developed checklist. This study does not require approval by an ethics board. It will provide an overview of sex and gender considerations in European CPGs in the field of internal medicine regarding the time frame β Clinical practice guidelines CPGs in internal medicine and its subspecialties produced in the last decade in Europe will be analysed to provide the first systematic overview of the inclusion of sex-related and gender-related knowledge into CPGs.
