Official websites use. Share sensitive information only on official, secure websites. These tools are important reagents for scientists studying human health and disease and will facilitate the development of new medicines.
It is therefore not surprising that pharmaceutical companies are joining Target , contributing both knowledge and reagents to study novel proteins. Here, we present a brief progress update on Target and highlight some of industry's contributions. Formulated in , by public funders and scientific representatives from academia and the drug discovery industry, Target is focused on developing a pharmacological tool for each human protein by the year The goals of Target can only be accomplished by expanding hit-finding approaches beyond traditional methods.
Traditional hit-finding methods tend to be prohibitively resource-intensive and limited to large private sector entities. In CACHE, 17 computational chemists have three unique opportunities per year to benchmark their algorithms and processes.
In every challenge, each participant predicts up to ligands for new, expert-curated targets. The predicted compounds are purchased, evaluated experimentally in target-specific assays, and binding data returned to participants.
For methods that successfully predicted binders, a second and final round of predictions is performed making use of the experimental results from the first round, if possible. OCN is an international, open, and inclusive chemistry network that exists to bring together chemists and biochemists in the community with a common aim of developing probes to understudied targets.
