Official websites use. Share sensitive information only on official, secure websites. Gastro-oesophageal reflux disease is a common condition with a complex pathophysiology. Despite the spectrum of abnormalities, gastric acid has a central role in mucosal damage, and the mainstay of medical treatment is suppression of gastric acid secretion.
The results of antisecretory treatment as assessed by endoscopic healing are reviewed. Improved healing rates can be obtained by increasing the degree of acid suppression or the length of treatment.
The addition of a prokinetic agent may be beneficial. The degree and rate of healing seem to be related to the reduction in oesophageal acid exposure and thus may correlate with the degree and duration of acid suppression over 24 hours obtained by the various treatments. The underlying pathophysiology is unchanged, however, and long term treatment may be needed to maintain remission. These references are in PubMed.
This may not be the complete list of references from this article. As a library, NLM provides access to scientific literature. Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease.
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