Official websites use. Share sensitive information only on official, secure websites. Correspondence to: Onder Canguven. Literature support that vitamin-D is important for different systems of the human body including, but not limited to endocrine and immune systems, vasculature and endothelial function of the body.
Male erectile function depends on many factors and can be perceived as a health indicator of the body. Epidemiological data have shown that vitamin-D deficiency is also associated with erectile dysfunction. In this review, our aim is to interpret the mechanisms by which vitamin-D might regulate anatomy and physiology of penis.
Evidence showed that vitamin-D is needed for an adequate erectile function. Briefly, vitamin-D is crucial for a better healthy body and sexual activity. Human sexual activity is the manner in which humans experience and express their sexuality.
Male penile erection is a physiological phenomenon in which the penis becomes firm, engorged, and enlarged in response to sexual arousal during sexual activity [ 1 ]. Penile erection is the result of a complex interaction of psychological, neural, vascular, and endocrine factors in the presence of a normal penis anatomy [ 2 ].
Penile erection is initiated by nitric oxide NO , a potent vasodilator, released from the nerve endings, further production of NO depends on increased blood flow which is also known as shear stress [ 3 ]. In most vascular beds, the NO is released by a stimulus that increases the shear stress over the endothelium. Endothelial dysfunction is a key variable in the pathogenesis of atherosclerosis and its complications, including erectile dysfunction ED.
